They deal Fire or Lightning Damage, or cast a Stone Curse, on monsters that walk over the activated rune. Runes are dropped by chests and monsters and randomly sold by Adria the Witch. Runes are trap-like objects that can only be found in the Hellfire expansion. Their role changed again in Diablo III, where they are no longer items, but affect the way skills work. They were reintroduced in Diablo 2: Lord of Destruction as a new type of socketable item along with jewels. They made their first appearance in the Diablo expansion Hellfire as usable items.
Transmute non-ethereal armor, a Ral rune and a flawed gem to repair the armor's durability and restore the armor's skill charges.Runes are magical symbols carved on rock. Transmute non-ethereal armor and a Ral rune to repair the armor's durability. Transmute a basic rare armor, a Ral rune, a Thul rune, and a perfect amethyst to upgrade the rare armor's base armor type to its exceptional version. Transmute a basic unique weapon, a Ral rune, a Sol rune, and a perfect emerald to upgrade the unique weapon's base weapon type to its exceptional version. Transmute a normal quality unsocketed helm, a Ral rune, a Thul rune, and a perfect sapphire to add a random number of sockets to the helm. Transmute a normal quality unsocketed weapon, a Ral rune, an Amn rune, and a perfect amethyst to add a random number of sockets to the weapon. Transmute magic gauntlets or exceptional/elite version (war gauntlets or ogre gauntlets), a jewel, a Ral rune, and a perfect emerald to create crafted Safety gloves. Transmute a magic amulet, a jewel, a Ral rune, and a perfect amethyst to create a crafted Caster amulet. Transmute a magic helm or exceptional/elite version (casque or armet), a jewel, a Ral rune, and a perfect ruby to create a crafted Blood helm. Transmute magic chain boots or exceptional/elite version (mesh boots or boneweave boots), a jewel, a Ral rune, and a perfect sapphire to create crafted Hit Power boots. Transmute three Ral runes to create one Ort rune. Ral runes are used in eleven Horadric Cube recipes. King's Grace 'AmnRalThul' sword or scepter. 
Insight 'RalTirTalSol' polearm, staff or missile weapon.Ancient's Pledge 'RalOrtTal' off-hand armor.Diablo II: Resurrected Review - Pile Of Old Bones
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